Description
This course focuses on the techniques, the instrumentation and applications of Mass Spectrometry in bioanalysis. The lectures give all the basics to understand Mass Spectrometry, including principle, ion sources, mass analyzers, detectors, data handling and spectral interpretation. A special attention is also put on separation techniques used in combination with Mass Spectrometry, and how to hyphenate such techniques. Finally, multiple external speakers from university, medical centers, or (pharma) industry highlight how Mass Spectrometry can be used in today’s science, within different bioanalytical applications including metabolomics, proteomics, glycomics, intact protein analysis, lipidomics, Mass Spectrometry imaging or forensic sciences.
Coordinator
Dr. I. Kohler (i.kohler@lacdr.leidenuniv.nl)
Admission requirements
Master students BPS. Analytical Chemistry (Analytical Biosciences) or Systems Pharmacology (3rd year courses bachelor study BFW).
Mode of instruction
Lectures, self study and student presentations.
Reading list
Will be announced during the lectures.
Course objectives
The main objectives of the course BMS is to provide the students with:
The basic working principle of mass spectrometry (MS), including background, mechanisms, ionization, instrumentation, spectral interpretation, as well as hyphenation to chromatographic and electrophoretic techniques;
The latest developments of MS technology and future trends in bioanalysis;
A deep insight of the current MS applications in bioanalysis, biomedical and biopharmaceutical research.
Assessment method
The assessment comprises a group assignment (presentation, 30% of the final grade) and a written exam (70% of the final grade).
Timetable
The course is taught in January 2019.
Registration
Application via uSis. Registration closes 1 month before the start of the course or earlier if the maximum number of students is reached.
Remarks
A minimum of 5 participants is required. The maximal amount of participants is 40.