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Mechanisms of disease 2



In this six week course the mechanisms of cancer development and haemodynamic disorders will be discussed in relation to genetics and clinico-pathological aspects. In a multidisciplinary integrated approach students will learn the basic principles of tumor development and metastasis including diagnostics and the different treatment modalities (surgery, radiation, chemo- and hormonal treatment including personalized medicine. In the theme haemodynamic disorders the mechanisms of thrombosis and atherosclerosis will be discussed, partly in relation to cancer development.

Course objectives

The student:

  • knows and understands the major aspects of the etiology, pathogenesis and pathophysiology of neoplasia development and progression at molecular, cellular, tissue, organ and patient level.

  • identifies the basic mechanisms of disease in the development of malignancies and hemodynamic disorders including haemodynamic disorders (e.g. thrombosis).
    describes the differences between benign and malignant tumors

  • knows the principles of tissue invasion and metastasis

  • knows how to diagnose, stage and treat patients with malignancies

  • is aware of the impact of malignancies and its treatment on patients physical, mental and social comfort at short and long term.

  • knows how the organization of cancer care in the Netherlands has been organized, including terminal and palliative

Mode of instruction

Lectures, workgroup meetings, patient demonstrations, self-study excersises

Assessment method

Testing is done by means of a summative mid-point exam, a formative mid-point exam and a final exam. Some open questions will be asked, as well as extended matching and multiple choice questions.


  • Kumar V., Abbas A.K. and Fausto N., Robbins and Cotran Pathologic basis of disease, Elsevier Saunders, 8th edition, 2009

  • Van de Velde C.J.J. e.a., Oncologie, 8th edition, 2011

  • Kumar P., Clark., Clinical Medicine, 7th edition, 2009

  • TRC section for farmacotherapie

  • Turnpenny P. Emery’s elements of medical genetics, 14e druk


Secretariat department of Pathology