In this six week course the mechanisms of cancer development and haemodynamic disorders will be discussed in relation to genetics and clinico-pathological aspects. In a multidisciplinary integrated approach students will learn the basic principles of tumor development and metastasis including diagnostics and the different treatment modalities (surgery, radiation, chemo- and hormonal treatment including personalized medicine. In the theme haemodynamic disorders the mechanisms of thrombosis and atherosclerosis will be discussed, partly in relation to cancer development.
knows and understands the major aspects of the etiology, pathogenesis and pathophysiology of neoplasia development and progression at molecular, cellular, tissue, organ and patient level.
identifies the basic mechanisms of disease in the development of malignancies and hemodynamic disorders including haemodynamic disorders (e.g. thrombosis).
describes the differences between benign and malignant tumors
knows the principles of tissue invasion and metastasis
knows how to diagnose, stage and treat patients with malignancies
is aware of the impact of malignancies and its treatment on patients physical, mental and social comfort at short and long term.
knows how the organization of cancer care in the Netherlands has been organized, including terminal and palliative
Mode of instruction
Lectures, workgroup meetings, patient demonstrations, self-study excersises
Testing is done by means of a summative mid-point exam, a formative mid-point exam and a final exam. Some open questions will be asked, as well as extended matching and multiple choice questions.
Kumar V., Abbas A.K. and Fausto N., Robbins and Cotran Pathologic basis of disease, Elsevier Saunders, 8th edition, 2009
Van de Velde C.J.J. e.a., Oncologie, 8th edition, 2011
Kumar P., Clark., Clinical Medicine, 7th edition, 2009
TRC section for farmacotherapie
Turnpenny P. Emery’s elements of medical genetics, 14e druk