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Physiology, Basic Concepts

Vak 2018-2019


Monday 21 January 2019 – Friday 1 March 2019.

Admission requirements

General knowledge of the English language, biology, mathematics, physics, and chemistry as required for students to be accepted for Biomedical Sciences.


The course Physiology, Basic Concepts, consists of two main themes.

**Theme 1. Cardiovascular and Respiratory System (prof.dr. Steendijk)
* Anatomy of the heart and vessels
* Cardiac electrophysiology and ECG
* Molecular mechanisms
* Excitation-contraction coupling
* Cardiac muscle physiology and cardiac function
* Gas exchange and transport
* Cardio-pulmonary interaction
* Cardio-vascular interaction
* Neurohormonal control
* Exercise and heart failure

**Theme 2. Kidneys and Homeostasis (dr. Gaasbeek)
* Anatomy of the kidneys
* Renal clearance and blood flow
* Regulation of glomular filtration rate and renal blood flow
* Tubular transport systems and functions
* Urine dilution an concentration
* Acid-base regulation
* Osmolality and volume regulation

Course objectives

The student:
* describes and defines the structure and functions of the cardiovascular system, the respiratory system and the kidneys
* relates the functions of organs/organ-systems to the specific anatomical, mechanical and (with regard to the heart) electrical properties
* describes the role of these organ system in homeostasis of the organism
* illustrates by clinical examples how several pathophysiologic conditions of organs/organ-systems can be viewed from basic physiological principles

Mode of instruction

Plenary lectures, interactive seminars, practicals, working groups, e-learning, rehearsal exams.

Assessment method

Two exams. Exam 1: Cardiovascular System (50%); Exam 2: Kidneys and Homeostasis (50%). Final course grade is the average of exam 1 and exam 2, but each individual exam should score at least grade 4.5.

Exam dates

The exam dates can be found on the schedule website.

Reading list

  • Moore: Clinically oriented anatomy (7th edition, 2013)
  • Pawlina: Histology (7th edition, 2015)
  • Boron: Medical Physiology (3rd edition)
  • Herring, H. & D.J. Paterson: Levick's Introduction to Cardiovascular Physiology. (6th ed. 2018)