This course is a core course in the MSc Life Science and Technology programme and an elective course for MSc Chemistry Chemical Biology students.
Students with a BSc degree in MST or LST should have sufficient background knowledge for the BNT course. Other students should be familiar with basic concepts in Nanoscience, Nanotechnology, Thermodynamics and Statistical Thermodynamics.
Bionanotechnology studies the implementation of nanomaterials to understand biology. Bionanotechnology finds many applications in chemical biology research, DNA/protein sequencing, drug delivery systems, sustainable energy, and biosensors.
This course introduces nanotechnologies from a chemical perspective and details to what extend nanotechnology can be used to study biology. A particular focus of the course will be given to graphene, other two-dimensional materials, nanopores, and nanoparticles – with the objective to understand why those new nanomaterials are so much in the spot lights of scientific and academic research. Basic concepts such as bottom-up and top down nanofabrication, surface functionalization, biomolecular sequencing, wetting transparency, colloidal stability, nanocrystal nucleation & growth, electronic device nanophysics, and single molecule biochemistry, are explained first. Then, these elementary blocks will be put in perspective for applications: field-effect biosensing, nanopore sensing, current DNA sequencing technologies, and drug-delivery with nanoparticles.
Understanding and knowledge of the use of nanotechnology in the design of sensors, particularly the use of nanopores and single molecule sensors
Knowledge of the theoretical foundations of phase diagrams in the context of van der Waals theory and Classical Nucleation Theory
Understanding and knowledge of the properties of two dimensional materials (including graphene) in the design of biosensors
Knowledge of the theoretical principles that constitute the DLVO theory and the connection with Colloidal Stability
Knowledge of graphene properties, synthesis, transfer and device nanofabrication and microfabrication
Understanding of the experimental phenomenon of Wetting in terms of the Wetting Diagram and surface tensions involved, and rudimentary knowledge of the theoretical description of Wetting in terms of the Surface Potential
Knowledge of colloidal and nanoparticle-based drug delivery systems.
Mode of instruction
Lectures, problem solving, home work, writing a proposal, oral defense of the proposal
G.F. Schneider et al: “Single molecule detection with graphene: nanopores and beyond” (Chemical Society Reviews, 2015)*, “Chemical and biological sensing with a graphene surface” (Nanoscale, 2015)*, “Chemistry of graphene edges” (Angewandte Chemie, 2015)*; handouts; articles.
Written exam (2/3 of the grade) and a proposal+defense (1/3).