The role of metabolomics in biological and pharmaceutical research will be described as well as the methods available (chromatographic methods, mass spectrometry, NMR spectrometry). The advantages as well as disadvantages of the various methods will be dealt with, using various applications as examples to illustrate this. The chemometric methods used to deal with the large data sets will be demonstrated.
Coordinator
Prof.dr.R.Verpoorte: verpoort@chem.leidenuniv.nl
Methods of instruction
Lectures, interactive problem solving with real-life examples, demonstration of the methods
Study material
Handout will be given during the course
Examination
Written examination
Course requirements/recommendations
Basic knowledge of natural products chemistry, chromatography and structure elucidation, which can be obtained from other short courses of the MSc-track Biodiversity and Natural Products
Time table
One full week course
Application
Via secretary Section Metabolomics, Anneke Poels:
A.Poels@chem.leidenuniv.nl, tel 071 5274510, Gorlaeus laboratories Room HB024
Blackboard
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Course objective
Getting accustomed to the systems biology approach in studying biological problems by using a holistic, non-targeted chemical analysis of an organisms phenotype under certain conditions.
Remarks
This course is an introductory course. Once a year an international advanced course is given for which also a few Leiden University students (MSc and PhD level) can participate.