nl en

Physiology, Advanced Concepts



Monday March 5th – Friday March 23rd 2018.

Admission requirements

The course Physiology, Advanced Concepts, is meant for the student who has already followed the course Physiology, Basic Concepts, or has a comparable level of knowledge on cardiovascular, respiratory and renal physiology.


This course focuses on impaired circulation as a result of inflammation, sepsis, endothelial dysfunction, thrombosis, atherosclerosis and vascular remodelling and its consequences for heart, lung and kidney physiology. Subtopics that will be discussed during the course are:

  • endothelial (dys)function

  • (ab)normal hemostasis

  • sepsis

  • vascular responses to Toll-like receptor activation

  • inflammatory & ischemic kidney disease

  • pulmonary arterial hypertension

  • atherosclerosis, coronary artery disease & myocardial infarction

  • heart failure: hemodynamic & electrophysiological effects

Course objectives

After having followed this course, students should have a clear understanding of the major pathophysiological processes involved in blood flow impairment and its consequences for heart, lung and kidney function.

Mode of instruction

This course consists of lectures, seminars, working groups and self-study assignments.

Assessment method

Multiple choice exam.

Exam dates

  • Exam: Friday March 23rd 2018 from 9.00-12.00h

  • Re-exam: Wednesday July 11th 2018 from 13.00-16.00h

Reading list

  • Boron, W. & Boulpaep, E., Medical Physiology, 3th ed., 2016, Elsevier.

  • Levick JR. Introduction to cardiovascular physiology. Fifth edition. 2010. Hodder Arnold, London, United Kingdom.

  • Robbins and Cotran Pathologic Basis of Disease. V. Kumar, A.K. Abbas, J.C. Aster, 2015, 9th edition, Elsevier, Philadelphia. PA.

  • Versteeg HH et al. New fundamentals in hemostasis. Physiol Rev. 2013; ;93:327-358.

  • Other selected scientific papers and parts of other text books.