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Prospectus

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Biomedical imaging

Course
2017-2018

Overview
During the first weeks of the half-minor, the broad spectrum of diagnostic imaging techniques will be discussed, while relating them to conditions they are often used for. Cardiovascular imaging and CT, neuro imaging and MRI, interventional radiology and ultrasound, will all be highlighted. In the weeks after, other roles of radiology will be emphasized, such as oncology and nuclear medicine, pathology and microscopic imaging and image-guided surgery.

Learning goals
1. evaluate the role of CT- and MRImaging in diagnosis and therapy of patients with cardiovascular, oncologic or neurologic disease;
2. indicate the scope and limitations of the various radiologic modalities (CT, MRI, SPECT, PET, US, Fluorescence);
3. establish which criteria (medical, physics and costs) are instrumental for the selection of an imaging modality /assessment, using modalities mentioned above in goal-2;
4. evaluate (criticize and assess) the application of new clinical imaging research lines (e.g. fluorescence imaging methods, hybrid modalities as PET-MRI, and image guided navigation techniques);
5. apply specific clinical challenges in neurology, oncology, or cardiology to design application driven preclinical imaging research projects using cell and/or animal models.
6. apply the insight gained in imaging course to write a well motivated request for a specific radiological examination, based on a specific patient case (cardiovascular, oncologic or neurologic disease) taking into account practical aspects, cost-effectiveness and risks of this examination for the patient (especially: radiation burden and possible adverse effects of contrast agents);
7. indicate in which clinical situation image guided interventions (cardiological, neurological or oncological), using Ultrasound, CT, Angiography, Nuclear Medicine, and Fluorescence imaging may
improve patient care.
8. based on neurological and oncological symptoms in a patient envisage which microscopy/pathology approaches could be applied to analyze the molecular aspects of the disease.
9. evaluate the (potential) value of biomedical imaging in two of the LUMC profile areas: Vascular and regenerative medicine, Immunity, Infection Diseases and Tolerance, Translational Neurosciences, Cancer Pathogenesis and Therapy, Ageing, Innovation in Health Strategy Quality of Care.

Modes of education
Lectures, workgroups, patient demonstrations, laboratory visits, practicals

Assessment
Case presentation (5x)
Presentation per student of one or more neuroradiology cases.
Cases have to be prepared in written form (ppt) and have to be handed in. See Schedule.
Passed / Not passed

EXAM (open questions)
Knowledge obtained in week 1-4 is being tested. Mark counts for 20% of the final mark.
See Schedule.
To make sure all results are criticized equally, the three coordinators will alternate per exam.
Students receive their marks at the end of Week 5

EXAM-2 (open questions)
Knowledge obtained in week (1-4), 5,6,7 is being tested. Mark counts for 20% of the final mark
See Schedule.
To make sure all results are criticized equally, the three coordinators will alternate per exam.
Students receive their marks at the end of Week 8

Oral presentation of topics for debate:
Presentation in a group of 5 students about the role of biomedical imaging in one of the LUMCprofile
areas. See Schedule.
Mark counts for 20% of the final mark.

Radiological request:
Write three requests for radiological/pathological examination. Patient cases will provided on
cardiovascular disease, neuro imaging, and oncology. Hand-in date: See Schedule.
Inform students about their mark at the end of week 11. Mark counts for 20% of the final mark.

Written report:
Prepare a report of 1500-2000 words: Opinion Paper on the role of biomedical imaging for a specific topic related to the debate in which the student participates. Hand in on Friday at week 10. To make sure all casus are criticized equally, a minimum of two coordinators will give a mark. Inform students about their mark at the end of week 11. Mark counts for 20% of the final mark. Students will be informed about their final mark within 3 weeks after the end of the course.
The assessment criteria for this report are described in a Rubik format, which is included in the module book. Study load of the report is one week work.

**Examination committee: **
A.R. van Erkel (MD. PhD), F.W.B. van Leeuwen (PhD), T. Buckle (PhD), J. Doornbos (PhD)

Examination dates:
29-Sep-2017, 20-Oct-2017, 01-Nov-2017 (With debriefing immediately after the examinations)
Debriefing date for final paper: Personal debriefing is optional (on request): 24-Nov-2017

Literature:
Papers will be provided per week via Blackboard.
The following websites give a fair impression of topics covered in this half minor:

General radiology
http://www.med-ed.virginia.edu/courses/rad/ Virginia University
http://eradiology.bidmc.harvard.edu/
http://www.radiologyeducation.com/

CT
http://www.ctisus.com/ CT-anatomy, Protocols, Teaching files, etc
http://en.wikipedia.org/wiki/Virtual_colonoscopy CT colonography

Ultrasound
http://en.wikipedia.org/wiki/Ultrasound_imaging Basics of ultrasound
http://en.wikipedia.org/wiki/Obstetric_ultrasonography

MRI
https://www.imaios.com/en/e-Courses/e-MRI basics
http://en.wikipedia.org/wiki/Mri basics
http://www.cis.rit.edu/htbooks/mri/ basic physics
http://en.wikipedia.org/wiki/Functional_magnetic_resonance_imaging fMRI
http://en.wikipedia.org/wiki/Statistical_parametric_mapping fMRI

Nuclear Medicine
http://www.radiologyinfo.org/en/info.cfm?PG=gennuclear
http://www.snmmi.org/AboutSNMMI/Content.aspx?ItemNumber=6433 What is Nuclear Medicine
http://en.wikipedia.org/wiki/Pet_scan What is PET

Image Guided Surgery
http://en.wikipedia.org/wiki/Fluorescence_image-guided_surgery

Mass spectrometry Imaging
http://en.wikipedia.org/wiki/Mass_spectrometry_imaging
http://www.maldi-msi.org/ MALDI

Micro-MRI (mouse atlas) preclinical imaging
http://www.emouseatlas.org/emap/home.html

Microscopy: for fundamentals of Light Microscopy, see
http://en.wikipedia.org/wiki/Microscopy
http://en.wikipedia.org/wiki/Fluorescence_recovery_after_photobleaching
http://en.wikipedia.org/wiki/Förster_resonance_energy_transfer

Electron Microscopy
http://en.wikipedia.org/wiki/Electron_microscopy

Allen Brain Atlas
http://www.brain-map.org/
http://www.brainscope.nl/