Prospectus

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Blood-Brain Barrier: Drug Transport to the Brain

Course 2011-2012

The development of new drugs with an action on the central nervous system (CNS) is notoriously difficult. For a proper CNS effect, the drug should have the ability to cross the BBB, and then has to find its way to the relevant target site within the CNS. This course will address the role and function of the Blood-Brain Barrier (BBB) and brain tissue distribution in research concerning CNS drug development, CNS drug delivery and CNS diseases. It will provide profound insight in the complex function of the BBB with regard to transport kinetics in health and disease.
The series of lectures will include the following themes; 1) basic aspects of the BBB, 2) In vitro and in vivo methods for investigation of BBB transport and distribution within the brain, and 3) pharmaco-kinetics of CNS drug delivery.

Coordinator

Dr. E.C.M. de Lange

Students

Students of Bio-Pharmaceutical Sciences and Biomedical Sciences

Admittance demands

Theme drug effects (2)

Method of instruction

lectures

Required reading

a handout will be given at the beginning of the Lecture Series

Examination

written exam

minimal number of students

minimum of 8 students

Time table

Mondays:
June: 11, 18, 25
July: 2 and 9

Time: 10.00—12.00 h

Exam: Friday, July 13, 9 AM, C1

Application

Via e-mail: l.lange@lacdr.leidenuniv.nl
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