Bio-Pharmaceutical Sciences: Systems Pharmacology
Systems Pharmacology is a specialisation of the Master’s programme Bio-Pharmaceutical Sciences of Leiden University. Systems Pharmacology offers a unique combination of cutting-edge experimental training in the field of metabolomics and translational systems biology with quantitative pharmacological modelling. This is used to better understand and predict drug-induced modulation of systemic disease networks. Research Project 1 will be conducted at the cluster Systems Pharmacology of the LACDR on one of the research themes described below. Please check the tab “More info” for the general outline of the programme.
The cluster works with theoretical frameworks that, through extrapolation and prediction, can be used for drug development and individualized therapies. Therefore we work with an advanced understanding of factors that govern the fate of the drug in the body (pharmacokinetics) in relation to drug effects (pharmacodynamics). Improvements of the quality of the theoretical frameworks are achieved by inclusion of multiple quantitative and objective measures as a composite biomarker for disease condition and treatment effects.
Another aim of the cluser is to develop new analytical strategies for personalized health strategies and personalized medicine. We specifically focus on metabolomics-driven systems biology to obtain new insights in disease mechanisms. We develop novel phenotypic read-outs for diagnosis and patient stratification for treatment based on metabolomics, UPE and organ-on-a-chip technologies and methods.