Prospectus

nl en

Bio-Pharmaceutical Sciences: Systems Pharmacology

Master

Systems Pharmacology is a specialisation of the Master’s programme Bio-Pharmaceutical Sciences of Leiden University. Systems Pharmacology offers a unique combination of cutting-edge experimental training in the field of metabolomics and translational systems biology with quantitative pharmacological modelling. This is used to better understand and predict drug-induced modulation of systemic disease networks. Research Project 1 will be conducted at the division Systems Biomedicine and Pharmacology of the LACDR on one of the research themes described below.

The division works with theoretical frameworks that, through extrapolation and prediction, can be used for drug development and individualized therapies. Therefore we work with an advanced understanding of factors that govern the fate of the drug in the body (pharmacokinetics) in relation to drug effects (pharmacodynamics). Improvements of the quality of the theoretical frameworks are achieved by inclusion of multiple quantitative and objective measures as a composite biomarker for disease condition and treatment effects.

Another aim of the division is to develop new analytical strategies for personalized health strategies and personalized medicine. We specifically focus on metabolomics-driven systems biology to obtain new insights in disease mechanisms. We develop novel phenotypic read-outs for diagnosis and patient stratification for treatment based on metabolomics, UPE and organ-on-a-chip technologies and methods.

First and Second Year

Course EC Semester 1 Semester 2

Mandatory courses:
Advanced Academic Skills and Career Orientation 3
Introduction Course Bio-Pharmaceutical Sciences 4
Literature Study LACDR 7

Research Project 1 at the division of Systems Pharmacology at the LACDR or the Division of Clinical Pharmacology at the CHDR
Research Project 1 - Practical Work 44
Research Project 1 - Thesis 5
Research Project 1 - Oral Presentation 2

The MSc programme of Bio-Pharmaceutical Sciences offers the following Lecture Series in the academic year 2018–2019 (one of these is mandatory):
Regulation of Drug Safety 4
Atherosclerosis 4
Bioanalytical Mass Spectrometry 4
Biophysics and Bioengineering for Pharmaceutical Sciences 4
Capillary Electrophoresis-Mass Spectrometry for Metabolomics 4
Signal Transduction and Hallmarks of Cancer 4
Quantitative Pharmacology 4
Model organisms in cancer drug discovery and development 4
Drug Delivery 4
Cell adhesion signaling in health and disease 4
Blood-Brain Barrier: Drug Transport to the Brain 4

Optional courses in the academic year 2018–2019 (list is not restrictive):
IP Law in Science 5
Science Methodology (SCM) 4
Science and the public: contemporary and historical perspectives 6

More info

Course Schedules are published via Blackboard. An overview of Exam Dates as well as Class numbers for enrolling for courses and exams in uSis can be obtained here

General outline of the MSc programme of the research track Systems Pharmacology:

Level EC
Introduction Course Bio-Pharmaceutical Sciences: Systems Pharmacology 500 4
Research project 1, at the division of Systems Biomedicine Pharmacology
- practical work 600 44
- thesis 600 5
- oral presentation 600 2
Research project 2, (preferably in another discipline of BPS, not restricted to the Faculty of Mathematics and Natural Sciences)
- practical work 600 31
- thesis 600 5
Literature study plus thesis 500 7
Lecture series 1 (in BPS) 500 4
Course Advanced Academic Skills and Career Orientation 500 3
Optional courses or traineeships 400–600 (max 12 EC < 400) 15

Attending more than one lecture series of BPS is optional and may be part of the programme component ‘Optional courses’.